No letterpress compositor would employ an en quad as an interword space, except possibly when justifying.
A standard job case contains, along with the various quads, typemetal spaces in 3 sizes: 3-to-the-em, 4-to-the-em, and 5-to-the-em. There are also "thin" spaces, not proportional to the font size: "brass" at 1 point, "copper" at 1/2 point.
These spacings are often written as 3/em, &c., but are pronounced as fully written out, to avoid confusion with the 3em and suchlike quads.
A 3-to-the-emis the absolute standard interword space, which is why they are located in the large and central compartment as shown here: http://en.wikipedia.org/wiki/California_Job_Case <cid:part1.03010301.04010302@comcast.net>. (You have to scroll down a bit to see the clear diagram provided.)
As to intersentence spacing, the battle rages on, as we have seen in this forum. Personally, I use an em quad with handset type. More arcana can be found at: http://en.wikipedia.org/wiki/Sentence_spacing <cid:part2.00090403.02050803@comcast.net>.
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